Humanized Mouse Xenograft Model

Lanli Biology can provide humanized mice such as PD-1, PD-L1, CTLA-4, B7H4, OX40, CD137, CD40, TIM3, LAG3, etc. At the same time, we can use humanized mouse tumor cell lines to construct the humanized mouse tumor model you need.

1. Humanized mice:

Single target humanization	PD-1，PD-L1，CTLA-4，B7H4，OX40，CD137，CD40，TIM3，LAG3，CD47，4-1BB，B7H3，CD27，CD3E，BTLA，CD226，CD28， GITR，SIRPA，TIGIT，CSF1R，CD73，CD38，NKG2A，CD94，VSIR，CD22，CD33，CD52，TFR1，TNFR2，CD45，CD155，CD43， CD36，VEGR2，BCAM，OX40L
Dual-target humanization	PD-L1/TIM3，PD-1/B7-H3，TNFR2/TNFR1，OX40/OX40L，CD3E/4-1BB，CD3E/CD20，PD-1/TIM3，PD-L1/4-1BB，PD-L1/CD40PD-L1/CD27，PD-L1/CTLA4，CTLA4/4-1BB，4-1BB/4-1BBL，CTLA4/GITR，CD94/NKG2A，PD-L1/TIGIT，PD-L1/OX40，PD-1/OX40，PD-L1/LAG3，CTLA4/OX40，CTLA4/TIM3，PD-1/4-1BB，PD-1/CD27，CTLA4/LAG3，PD-1/CD40， SIRPA/CD47，PD-1/PD-L1，PD-1/LAG3，PD-1/CTLA4，4-1BB/CD40，CD3E/CD28
Triple-target humanization	PD-1/PD-L1/IL2RA，PD-1/PD-L1/GITR，PD-1/PD-L1/TIM3，PD-L1/SIRPA/CD47，PD-1/SIRPA/CD47，PD-1/PD-L1/4-1BB， PD-1/PD-L1/CTLA4，PD-1/PD-L1/TIGIT，PD-1/PD-L1/LAG3，PD1/LAG3/TIM3，PD-1/PD-L1/CD40，PD-1/PD-L1/OX40

2. Humanized mouse tumor cell lines:

MC38Cell line humanization	MC38/hEGFR，MC38/hPDL1-hFAPα,MC38/hCD47，MC38/hPD-L1，MC38/hEpCAM，MC38/hPSMA， MC38/hCLDN18.2，MC38/hHER2；
CT26.WTCell line humanization	CT26.WT /hEGFR，CT26.WT /hPSMA，CT26.WT /hGPC3，CT26.WT /hEpCAM；
Other cell line humanization	A20/hCD20，A20/hCD19，EMT6/hEGFR，RM-1/hPSMA，4T1/hPD-L1，B16F10/hPD-L1，EMT6/hHER2，B16F10/hHER2。

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